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楊春茂
教授, RN, 博士
楊春茂

聯絡資訊
  長庚大學護理系
桃園縣龜山鄉文化一路259號
電話: +886-3-2118800 分機5123
傳真: +886-3-2118800 ext. 5326
email: chuenmao@mail.cgu.edu.tw
學 歷
 
PhD 美國密州大學醫學院藥理/毒理研究所博士)    
       
獎 勵
 
教 學
 
 
 
研究領域
 
發炎性疾病之生理
藥理及病理致病機轉
 
研究
   

 論文發表
 

1. Hsieh, H.L., H.H. Wang, C.Y. Wu, W.H. Tung, and C.M. Yang.* Lipoteichoic acid induces matrix metalloproteinase-9expression via transactivation of PDGF receptors and NF-kB activation in rat brain astrocytes. Neurotoxicity Res.17:344–359, 2010, May. Neuroscience, 89/252=35.32%, IF=3.538.

2. Luo, S.F., Y.Y. Fang, H.L. Hsieh, P.L. Chi, C.C. Lin, L.D. Hsiao, C.C. Wu, J.S. Wang, and C.M. Yang.* Involvement of MAPKs and NF-kB in TNF-a-induced VCAM-1 expression in human rheumatoid arthritis synovial fibroblasts. Arthritis & Rheumatism, 62:105-116, 2010, JanRheumatology, 3/32=9.38%, IF=7.764.

3. Tung, W.H., H.L. Hsieh, and C.M. Yang.* Enterovirus 71 induces COX-2 expression via MAPKs, NF-κB, and AP-1 inSK–N–SH cells: Role of PGE2 in viral replication. Cell. Signal. 22:234-246, 2010, FebCell Biology, 65/184=35.33%, IF=4.315.

4. Wang, H.H., H.L. Hsieh, C.Y. Wu, and C.M. Yang.* Oxidized low-density lipoprotein-induced matrix metalloproteinase-9expression via PKC-d/p42/p44 MAPK/Elk-1 cascade in brain astrocytes. Neurotox. Res. 17:50–65, 2010, Jan.Neuroscience, 89/252=35.32%, IF=3.538.

5. Lin, C.C., I.T. Lee, Y.L. Yang, C.W. Lee, Y. R. Kou, and C.M. Yang.* Induction of COX-2/PGE2/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: role of TLR4-dependent NADPH oxidase activation. Free Radical. Biol. Med. 48:240-254, 2010, Jan ENDOCRINOLOGY & METABOLISM, 16/128=12.5%, IF= 5. 736.

6. Jou, M.J., T.I. Peng, L.F. Hsu, S.B. Jou, R.J. Reiter, C.M. Yang, C.C. Chiao, Y.F. Lin, and C.C. Chen. Visualization of melatonin's multiple mitochondrial levels of protection against mitochondrial Ca-mediated permeability transition and beyond in rat brain astrocytes. J. Pineal Res. 48:20-38, 2010, Jan. Neuroscience, 13/252=5.16%, IF= 7.227.

7. Wu, C.Y., P.L. Chi, H.L. Hsieh, S.F. Luo, and C.M. Yang.* TLR4-Dependent Induction of Vascular Adhesion Molecule-1 inRheumatoid Arthritis Synovial Fibroblasts: Roles of Cytosolic Phospholipase A2a/Cyclooxygenase-2. J. Cell. Physiol. 223:480-491, 2010, May. Physiology, 15/83=18.07%, IF=3.839.

8. Lee, I.T., C.W. Lee, W.H. Tung, S.W. Wang, C.C. Lin, J.C. Shu, and C.M. Yang.* Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses. Am. J. Pathol.176:1671-1684, 2010, AprPathology, 9/75=12%, IF=4.591.

9. Lee, C.W. I.T. Lee, C.C. Lin, H.C. Lee, W.N. Lin, and C.M. Yang.* Activation and induction of cytosolic phospholipase A2by IL-1b in human tracheal smooth muscle cells: Role of MAPKs/p300 and NF-kB. J. Cell. Biochem. 109:1045-1056, 2010, AprBiochemistry & Molecular Biology, 107/289=37.02%, IF=3.263.

10. Cheng, C.Y., C.T. Kuo, C.C. Lin, H.L. Hsieh, and C.M. Yang.* IL-1b induces expression of matrix metalloproteinase-9 and cell migration via a c-Src-dependent, growth factor receptor transactivation in A549 cells. Br. J. Pharmacol. 160:1595-1610, 2010, Aug. Pharmacology, 24/254=9.45%, IF=4.842.

11. Chu P.H., H.I. Yeh , H.H. Wu , R.C. Hong, T.F. Shiu, and C.M. Yang. Deletion of the FHL2 gene attenuates the formation of atherosclerotic lesions after a cholesterol-enriched diet. Life Sci. 86: 365–371, 2010, FebMedicine, Research & Experimental, 53/123=48.39%, IF=2.702.

12. Tung, W.H., I.T. Lee, H.L. Hsieh, and C.M. Yang.* EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MPAK/AP-1 and NF-kB in rat brain astrocytes. J. Cell. Physiol. 224: 376–386, 2010,Aug. Physiology, 15/83=18.07%, IF=3.839.

13. Lee, I.T., C.C. Lin, Y.C. Wu, and C.M. Yang.* TNF-a induces matrix metalloproteinase-9 expression in A549 cells: Role of TNFR1/TRAF2/PKCa-dependent signaling pathways. J. Cell. Physiol. 224:454-464, 2010. Physiology, 15/83=18.07%, IF=3.839.

14. Cheng, S.E., I.T. Lee, C.C. Lin, Y. R. Kou, and C.M. Yang.* Cigarette smoke particle phase extract induces HO-1 expression in human tracheal smooth muscle cells: Role of c-Src/NADPH oxidase/MAPKs/Nrf2 signaling pathway. Free Radical Biol. Med. 48:1410–1422, 2010, MayENDOCRINOLOGY & METABOLISM, 16/128=12.5%, IF= 5. 736.

15. Yang, C.M.,* S.F. Luo, H.L. Hsieh, P.L. Chi, C.C. Lin, C.C. Wu, and L.D. Hsiao. Interleukin-1b Induces ICAM-1 Expression Enhancing Leukocyte Adhesion in Human Rheumatoid Arthritis Synovial Fibroblasts: Involvement of ERK, JNK, AP-1 and NF-kB. J. Cell. Physiol. 224:516-526.  2010, AugPhysiology, 15/83=18.07%, IF=3.839.

16. Wang, H.H., H.L. Hsieh, C.Y. Wu and C.M. Yang.* Endothelin-1 enhances cell migration via matrix metalloproteinase-9 up-regulation in brain astrocytes. J. Neurochem. 113:1133-1149, 2010, JunNeuroscience, 55/252=21.83%, IF= 4.281.

17. Shih, R.H., S.E. Cheng, W.H. Tung, and C.M. Yang.* Up-regulation of heme oxygenase-1 protects against cold injury-induced brain damage: a laboratory-based study. J. Neurotrauma, 27:1477-1487. 2010, AugNeuroscience, 76/252=30.16%, IF=3.714.

18. Hsieh, H.L., H.H. Wang, C.Y. Wu, and C.M. Yang.* ROS-dependent c-Fos/AP-1 induction up-regulates heme oxygenase-1 expression by bradykinin in brain astrocytes. Antioxidants Redox Signal. 13:1829–1844, 2010, DecBiochemistry & Molecular Biology, 27/289=9.34%, IF=7.407.

19. Shih, R.H., I.T. LEE, H.L. Hsieh, Y.R. Kou, and C.M. Yang.* Cigarette smoke extract induces HO-1 expression in mousecerebral vascular endothelial cells: Involvement of c-Src/NADPH oxidase/PDGFR/JAK2/STAT3 pathway. J. Cell. Physiol. 225:741-750, 2010, NovPhysiology, 15/83=18.07%, IF=3.839.

20. Tung, W.H., H.W. Tsai, I.T. LeeH.L. Hsieh, W.J. Chen, Y.L. Chen, and C.M. Yang.* Japanese encephalitis virus induces matrix metalloproteinase-9 in rat brain astrocytes via NF-κB signalling dependent on MAPKs and reactive oxygen species. Br. J. Pharmacol. 161:1566-1583, 2010, DecPharmacology, 24/254=9.45%, IF=4.842.

21. Wang, H.H., H.L. Hsieh, and C.M. Yang.* Calmodulin kinase II-dependent transactivation of PDGF receptors mediates astrocytic MMP-9 expression and cell motility induced by lipoteichoic acid. J. Neuroinflammation, 7:84, 2010, Nov.Neuroscience, 32/252=12.7%, IF=5.408.

22. Shih, R.H. and C.M. Yang.*Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells. J. Neuroinflammation, 7:86, 2010, NovNeuroscience, 32/252=12.7%, IF=5.408.

23. Hsieh, H.L., H.H. Wang, W.B. Wu, P.J. Chu, and C.M. Yang.* Transforming growth factor-b1 induces matrix metalloproteinase-9 and cell migration in astrocytes: roles of ROS-dependent ERK- and JNK-NF-kB pathways. J. Neuroinflammation, 7:88, 2010, Dec. Neuroscience, 32/252=12.7%, IF=5.408.

24. Tung, W.H., H.L. Hsieh, I.T. Lee, and C.M. Yang.* Enterovirus 71 modulates a COX-2/PGE2/cAMP-dependent viral replication in human neuroblastoma cells: Role of the c-Src/EGFR/p42/p44 MAPK/CREB signaling pathway. J. Cell. Biochem. 112:559-570, 2011, FebBiochemistry & Molecular Biology, 107/289=37.02%, IF=3.263.

25. Cheng, S.E., C.C. Lin, I.T. Lee, C.K. Hsu, Y. R. Kou, and C.M. Yang.* Cigarette smoke extract regulates cytosolic phospholipase A2 expression via NADPH oxidase/MAPKs/AP-1 and p300 in human tracheal smooth muscle cells. J. Cell. Biochem. 112:589-599, 2011, FebBiochemistry & Molecular Biology, 107/289=37.02%, IF=3.263.

26. Lee, C.W., C.C. Lin, I.T. Lee, H.C. Lee, and C.M. Yang.* Activation and induction of cytosolic phospholipase A2 by TNF-a mediated through Nox2, MAPKs, NF-kB, and p300 in human tracheal smooth muscle cells. J. Cell. Physiol. 226:2103-2114, 2011, AugPhysiology, 15/83=18.07%, IF=3.839.

27. Wang, H.H., H.L. Hsieh, and C.M. Yang.* Nitric oxide production by endothelin-1 enhances astrocytic migration via the tyrosine nitration of matrix metalloproteinase-9. J. Cell. Physiol. 226:2244-2256, 2011, SepPhysiology, 15/83=18.07%, IF=3.839.

28. Lin, W.N., C.C. Lin, Cheng, S.E., and C.M. Yang.* Regulation of COX-2 and cPLA2 Gene Expression by LPS through the RNA-binding Protein HuR: Involvement of NADPH oxidase, ROS and MAPKs. Br. J. Pharmacol. 163:1691-1706,2011, AugPharmacology, 24/254=9.45%, IF=4.842.

29. Tung, W.H., H.L. Hsieh, I.T. Lee, and C.M. Yang.* Enterovirus 71 induces integrin β1/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells: Role of HO-1/CO in viral replication. J. Cell. Physiol. 226:3316-3329, 2011, DecPhysiology, 15/83=18.07%, IF=3.839.

30. Liang CJ, CP TsengC.M. Yang, and YH Ma. 20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-α in vascular smooth muscle cells. Br. J. Pharmacol. 163:815-825, 2011,JunPharmacology, 24/254=9.45%, IF=4.842.

31. Chi, P.L., S.F. Luo, H.L. Hsieh, I.T. Lee, L.D. Hsiao, Y.L. Chen, and C.M. Yang.* cPLAinduction and PGE2 release by IL-1b via the MyD88-dependent and cooperation of p300, Akt, and NF-kB pathway in human rheumatoid arthritissynovial fibroblasts. Arthritis & Rheumatism, 63:2905-2917, 2011, OctRheumatology, 3/32=9.38%, IF=7.764.

32. Shih, R.H., S.E. Cheng, L.D. Hsiao, Y.R. Kou, and C.M. Yang.* Cigarette smoke extract upregulates heme oxygenase-1 via PKC/NADPH oxidase/ROS/PDGFR/PI3K/Akt pathway in mouse brain endothelial cells. J. Neuroinflammation, 8:104, 2011, AugNeuroscience, 32/252=12.7%, IF=5.408.

33. Cheng, C.Y., H.C. Tseng, and C.M. Yang.* Bradykinin-mediated cell proliferation depends on transactivation of EGF receptor in corneal fibroblasts. J. Cell. Physiol. 227:1367-1381, 2012, AprPhysiology, 15/83=18.07%, IF=3.839.

34. Lin, C.C., W.N. Lin, S.E. Cheng, W.H. Tung, H.H. Wang, and C.M. Yang.* Transactivation of EGFR/PI3K/Akt involved in ATP-induced inflammatory protein expression and cell motility. J. Cell. Physiol. 227:11628-11638, 2012, Apr.Physiology, 15/83=18.07%, IF=3.839.

35. Chi, P.L., Y.W. Chen, L.D. Hsiao, Y.L. Chen, and C.M. Yang.* Heme oxygenase-1 attenuates IL-1b-induced cPLA2expression via a decrease in NADPH oxidase/ROS/AP-1 activation in human rheumatoid arthritis synovial fibroblasts.Arthritis & Rheumatism, 64:2114-2125, 2012, JulRheumatology, 3/32=9.38%, IF=7.764.

36. Yang, C.M.,* C.C. Lin, I.T. Lee, Y.H. Lin, Caleb M. Yang, W.J. Chen, M.J. Jou and L.D. Hsiao. Japanese encephalitis virus induces matrix metalloproteinase-9 expression via ROS/Src/PDGFR/PI3K/Akt/MAPKs-dependent AP-1 pathway in rat brain astrocytes. J. Neuroinflamamtion. 9:12, 2012, JanNeuroscience, 32/252=12.7%, IF=5.408.

37. Cheng, C.Y., H.L. Hsieh, L.D. Hsiao, and C.M. Yang.* PI3-K/Akt/JNK/NF-kB is essential for MMP-9 expression and outgrowth of human limbal epithelial cells on intact amniotic membrane. Stem Cell Res. 9:9-23, 2012, JulCell Biology, 75/184=40.76%, IF=3.693.

38. Hsieh, H.L., C.C. Lin, R.H. Shih, L.D. Hsiao and C.M. Yang.* NADPH oxidase-derived redox signal contributes to lipoteichoic acid-induced MMP-9 regulation in brain astrocytes. J. Neuroinflamamtion, 9:110, 2012, JulNeuroscience, 32/252=12.7%, IF=5.408.

39. Lee, I.T. and C.M. Yang.* Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochem Pharmacol. 84:581-590, 2012, Sep. (Review paper). Pharmacology/Pharmacy, 23/254=9.1%, IF=5.009.

40. Hsieh, H.L., C.C. Lin, H.J. Chan, Caleb M. Yang and C.M. Yang.* c-Src-dependent EGF receptor transactivation contributes to ET-1-induced COX-2 expression in brain microvascular endothelial cells. J. Neuroinflammation. 9:152,2012, JulNeuroscience, 32/252=12.7%, IF=5.408.

41. Lin, C.C., I.T. Lee, W.L. Wu, W.N. Lin, and C.M. Yang.* Adenosine triphosphate regulates NADPH oxidase activity leading to hydrogen peroxide production and COX-2/PGE2 expression in A549 cells. Am J Physiol Lung Cell Mol Physiol. 330:L401-L412, 2012, SepPhysiology, 14/83=16.87%, IF=4.080.

42. Lin, C.C., H.L. Hsieh, R.H. Shih, P.L. Chi, S.E. Cheng, J.C. Chen, and C.M. Yang.* NADPH oxidase 2-derived reactive oxygen species signal contributes to bradykinin-induced matrix metalloproteinase-9 expression and cell migration in brain astrocytes. Cell Communication & Signaling. 10:35, 2012, NovCell Biology, 90/184=48.91%, IF=3.378.

43. Lee, I.T., R.H. Shih, C.C. Lin, J.T. Chen, and C.M. Yang.* Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells. Cell Communication & Signaling, 10:33, 2012, Nov. Cell Biology, 90/184=48.91%, IF=3.378.

44. Lee, I.T., C.C. Lin, C.Y. Lee, P.W. Hsieh, and C.M. Yang.* Protective effects of (-)-epigallocatechin-3-gallate against TNF-a-induced lung inflammation via ROS-dependent ICAM-1 inhibition. J. Nutr. Biochem. 24:124-136, 2013, Jan.Nutrition & Diebetics, 14/77=18.18%, IF=3.794.

45. Cheng S.E., I.T. Lee, C.C. Lin, W.L. Wu, L.D. Hsiao, and C.M. Yang.* ATP Mediates NADPH oxidase/ROS generation and COX-2/PGE2 expression in A549 cells: Role of P2 receptor-dependent STAT3 activation. Plos One, 8:e54125, 2013,Jan. Multidisciplinary Sciences, 8/56=40.29%, IF= 3.234.

46. Yang C.M.,* H.L. Hsieh, C.C. Lin, R.H. Shih, P.L. Chi, S.E. Cheng, and L.D. Hsiao. Multiple factors from BK-challenged astrocytes contribute to the neuronal apoptosis: Involvement of astroglial ROS, MMP-9, and HO-1/CO system. Mol. Neurobiol. 47:1020-1033, 2013, Jun. Neuroscience, 36/252=14.29%, IF=5.137.

47. Lin, C.C., H.L. Hsieh, R.H. Shih, P.L. Chi, S.E. Cheng, and C.M. Yang.* Up-regulation of COX-2/PGE2 by endothelin-1 via MAPK-dependent NF-kB pathway in brain microvascular endothelial cells. Cell Communication & Signaling, 11:8,2013, JanCell Biology, 90/184=48.91%, IF=3.378.

48. Lee I.T., C.C. Lin, C.H. Wang, W.J. Cherng, J.S. Wang, and C.M. Yang.* ATP stimulates PGE2/cyclin D1-dependent VSMCs proliferation via STAT3 activation: role of PKCs-dependent NADPH oxidase/ROS generation. Biochem. Pharmacol. 85:954-964, 2013, AprPharmacology/Pharmacy, 23/254=9.1%, IF=5.009.

49. Yang C.M.,*  I.T. Lee, C.C. Lin, C.H. Wang, W.J. Cherng, and L.D. Hsiao. c-Src-dependent MAPKs/AP-1 activation is involved in TNF-a-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells. Biochem. Pharmacol. 85:1115-1123, 2013, AprPharmacology/Pharmacy, 23/254=9.1%, IF=5.009.

50. Tseng, H.C., I.T. Lee, C.C. Lin, P.L. Chi, S.E. Cheng, R.H. Shih, L.D. Hsiao, and C.M. Yang.* IL-1b promotes cornealepithelial cell migration by increasing MMP-9 expression through NF-kB- and AP-1-dependent pathways. Plos One, 8:e57955 2013, MarMultidisciplinary Sciences, 8/56=14029%, IF= 3.234.

51. Yen, F.L., M.H. Tsai, C.M. Yang, C.J. Liang, C.C. Lin, Y.C. Chiang, H.C. Lee, H.H. Ko, and C.W. Lee. Curcumin nanoparticles ameliorate ICAM-1 expression in TNF-a-treated lung epithelial cells through p47phox and MAPKs/AP-1 pathways. Plos One, 8: e63845, 2013, MayMultidisciplinary Sciences, 8/56=14029%, IF= 3.234.

52. Lo, H.M., C.L. Chen, C.M. Yang, P.H. Wu, C.J. Tsou, K.W. Chiang and W.B. Wu. The carotenoid lutein enhances matrix metalloproteinase-9 production and phagocytosis through intracellular ROS generation and ERK1/2, p38 MAPK, and RARβ activation in murine macrophages. J. Leukoc. Biol. 93: 723–735; 2013, MayHEMATOLOGY, 13/68=19.12%, IF=4.189.

53. Hsieh, H.L., C.C. Lin, L.D. Hsiao and C.M. Yang.* High glucose induces reactive oxygen species-dependent matrix metalloproteinase-9 expression and cell migration in brain astrocytes. Mol. Neurobiol. 48:601-614; 2013, Dec.Neuroscience, 36/252=14.29%, IF=5.137. 

54. Lin, C.C., I.T. Lee, W.B. Wu, C.J. Liu, H.L. Hsieh, Li-Der Hsiao, Chien-Chung Yang, and C.M. Yang.* Thrombin mediates migration of rat brain astrocytes via PLC, Ca2+, CaMKII, PKCa, and AP-1-dependent matrix metalloproteinase-9 expression. Mol. Neurobiol. 48:616-630, 2013, DecNeuroscience, 36/252=14.29%, IF=5.137.

55. Lee, I.T., C.C. Lin, W.N. Lin, W.L. Wu, L.D. Hsiao and C.M. Yang.* Lung inflammation caused by adenosine-5'-triphosphate is mediated via Ca2+/PKCs-dependent COX-2/PGE2 induction. International J. Biochem. Cell Biol. 45:1657-1668, 2013, AugCell Biology, 68/184=36.96%, IF=4.046.

56. Yang C.M.,* I.T. Lee, R.C. Hsu, H.L. Hsieh, H.C. Tseng, P.L. Chi, and L.D. Hsiao. NADPH oxidase/ROS-dependent PYK2 activation is involved in TNF-a-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells. Toxicol. Appl. Pharmacol. 272: 431-442, 2013, OctToxicology, 13/87=14.94%, IF=3.705.

57. Lee, I.T., C.C. Lin, S.E. Cheng, L.D. Hsiao, Y.C. Hsiao, and C.M. Yang.* TNF-a induces cytosolic phospholipase A2expression in human lung epithelial cells via JNK1/2- and p38 MAPK-dependent AP-1 activation. Plos One, 8(9):e72783. 2013, SepMultidisciplinary Sciences, 8/56=14029%, IF= 3.234.

58. Lee, I.T. and C.M. Yang.* Inflammatory signalings involved in airway and pulmonary diseases. Mediators of Inflammation. 791231, 2013, Apr. (Review paper). Immunology, 58/148=39.19%, IF= 3.236.

59. Hsieh, H.L. and C.M. Yang.* Role of redox signaling in neuroinflammation and neurodegenerative diseases. BioMed Research International. 484613, 2013, Dec.

60. Lin, C.C., I.T. Lee, P.L. Chi, H.L. Hsieh, S.E. Cheng, L.D. Hsiao, C.J. Liu, and C.M. Yang.* c-Src/Jak2/PDGFR/PKCd-dependent MMP-9 induction is required for thrombin-stimulated rat brain astrocytes migration. Mol. Neurobiol. 49:658-672, 2014, Apr. Neuroscience, 36/252=14.29%, IF=5.137.

61. Lin, C.C., H.L. Hsieh, P.L. Chi, C.C. Yang, L.D. Hsiao, and C.M. Yang.* Up-regulation of COX-2/PGE2 by ET-1 mediated through Ca2+-dependent signals in mouse brain microvascular endothelial cells. Mol. Neurobiol. 49:1256-1269, 2014,JunNeuroscience, 36/252=14.29%, IF=5.137.

62. Chi P.L., C.J. Liu, I.T. Lee, Y.W. Chen, L.D. Hsiao and C.M. Yang.* HO-1 induction attenuates TNF-a-induced cytosolic phospholipase A2 expression via inhibition of PKCa-dependent NADPH oxidase/ROS and NF-kB cascade. Mediators of Inflammation. 279171, 2014, Jan. Immunology, 58/148=39.19%, IF= 3.236.

63. Tsai, C.L., W.C. Chen, I.T. Lee, S.E. Cheng, and C.M. Yang.* c-Src-dependent transactivation of PDGFR contributes to TNF-a-induced MMP-9 expression and functional impairment in osteoblast-like MC3T3-E1 cells. Bone. 60: 186-197,2014, MarENDOCRINOLOGY & METABOLISM, 38/128=29.67%, IF=3.973.

64. Hsieh, H.L., P.L. Chi, C.C. Lin, C.C. Yang, and C.M. Yang.* Up-regulation of ROS-dependent matrix metalloproteinase-9 from high glucose-challenged astrocytes contributes to the neuronal apoptosis. Mol. Neurobiol. 50(2):520-33, 2014, Oct.Neuroscience, 36/252=14.29%, IF=5.137.

65. Yang, C.M.*, I.T. Lee, P.L. Chi, S.E. Cheng, L.D. Hsiao, and C.K. Hsu. TNF-a induces cytosolic phospholipase A2expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells. Am. J. Physiol. Lung Mol. Cell. Biol., 306 (6): L543-L551, 2014, Mar. Physiology, 14/83=16.87%, IF=4.080. 

66. Chi, P.L., Y.C. Chuang, Y.W. Chen, C.C. Lin, and C.M. Yang.* The CO donor CORM-2 inhibits LPS-induced vascular cell adhesion molecule-1 expression and leukocyte adhesion in human rheumatoid synovial fibroblasts. Br. J. Pharmacol., 171(12):2993-3009, 2014, JunPharmacology, 24/254=9.45%, IF=4.842.

67. Hsu C.K., I.T. Lee, C.C. Lin, L.D. Hsiao, and C.M. Yang.* Nox2/ROS-dependent human antigen R translocation contributes to TNF-a-induced SOCS-3 expression in human tracheal smooth muscle cells. Am. J. Physiol. Lung Mol. Cell. Biol., 306 (6): L521-L533, 2014, Mar. Physiology, 14/83=16.87%, IF=4.080.

68. Tsai, C.L., H.L. Hsieh, P.L. Chi, W.C. Chen, L.D. Hsiao, and C.M. Yang.* TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2, c-Src, MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells. J. Biomed. Sci. 21(1):12,2014, Feb. MEDICINE, RESEARCH & EXPERIMENTAL, 50/123=40.65%, IF= 2.763.

69. Cheng, S.E., I.T. Lee, C.C. Lin, and C.M. Yang.* Thrombin induces ICAM-1 expression in human lung epithelial cells via c-Src/PDGFR/PI3K/Akt-dependent NF-kB/p300 activation. Clin. Sci., 127(3):171-183, 2014, AugMEDICINE, RESEARCH & EXPERIMENTAL, 13/123=10.57%, IF=5.598.

70. Lee IT, Lin CC, Hsu CK, Wu MY, Cho RL, and Yang CM. * Resveratrol inhibits Staphylococcus aureus-induced TLR2/MyD88/NF-κB-dependent VCAM-1 expression in human lung epithelial cells. Clin. Sci., 127(6):375-390, 2014,SepMEDICINE, RESEARCH & EXPERIMENTAL, 13/123=10.57%, IF=5.598.

71. Chien, T.Y., H.L. Hsieh, P.L. Chi, and C.M. Yang.* PAR-1-dependent COX-2/PGE2 production contributes to cell proliferation via EP2 in primary human cardiomyocytes. Br. J. Pharmacol. 171(19):4504-19, 2014, OctPharmacology,24/254=9.45%, IF=4.842.

72. Hsu C.K., I.T. Lee, C.C. Lin, L.D. Hsiao, and C.M. Yang.* Sphingosine-1-phosphate mediates COX-2 expression and PGE2/IL-6 secretion via c-Src-dependent AP-1 activation. J. Cell. Physiol., 230(3):702-15, 2015, MarPhysiology, 15/83=18.07%, IF=3.839.

73. Lee, I.T., H.W. Liu, P.L. Chi,  C.C. Lin, L.D. Hsiao, and C.M. Yang.* TNF-a mediates PKCd/JNK1/2/c-Jun-dependent monocyte adhesion via ICAM-1 induction in human retinal pigment epithelial cells. Plos One, 10(2):e0117911. 2015,Feb. Multidisciplinary Sciences, 8/56=14.29%, IF= 3.234.

74. Lin, C.C., I.T. Lee, C.H. Hsu, P.L. Chi, L.D. Hsiao, and C.M. Yang.* Sphingosine-1-phosphate mediates ICAM-1expression and monocyte adhesion via p38 MAPK and p42/p44 MAPK-dependent Akt activation. Plos ONE, 10(3):e0118473, 2015, Mar. Multidisciplinary Sciences, 8/56=14029%, IF= 3.234.

75. Lin, C.C., H.L. Hsieh, H.W. Liu, L.D. Hsiao, and C.M. Yang.* BK induces cPLA2 expression via an autocrine loop involving COX-2-derived PGE2 in rat brain astrocytes. Mol. Neurobiol., 51:1103–1115, 2015, JunNeuroscience, 36/252=14.29%, IF=5.137.

76. Yang, C.M.*H.L. Hsieh, P.H. Yu, C.C. Lin, and S.W. Liu. IL-1b induces MMP-9-dependent brain astrocytic migration via transactivation of PDGF receptor/NADPH oxidase 2-derived reactive oxygen species signals. Mol. Neurobiol., 52(1):303–317, 2015, AugNeuroscience, 36/252=14.29%, IF=5.137.

77. Chi, P.L., C.C. Lin, Y.W. Chen, L.D. Hsiao, and C.M. Yang.* CO induces Nrf2-dependent heme oxygenase-1 transcription by cooperating with Sp1 and c-Jun in rat brain astrocytes. Mol. Neurobiol., 52(1):277–292, 2015, Aug. Neuroscience, 36/252=14.29%, IF=5.137.

78. Yang, C.M.*, I.T. Lee, C.C. Lin, Y.C. Tai, C.K. Hsu, H.L. Hsieh, P.L. Chi, and L.D. Hsiao. c-Src-dependent transactivation of EGFR mediates CORM-2-induced HO-1 expression in human tracheal smooth muscle cells. J. Cell. Physiol., 230(10):2351-2361, 2015, OctPhysiology, 15/83=18.07%, IF=3.839.

79. Chien, P.T., C.C. Lin, L.D. Hsiao, and C.M. Yang.c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy:role of COX-2 induction. Mol Cell Endocrinol. 409: 59–72, 2015, Jul.Endocrinology & Metabolism, 30/128=23.44%, IF=4.4051.

80. Lin, C.C., W.N. Lin, W.C. Hou, L.D. Hsiao, and C.M. Yang.Endothelin-1 induces VCAM-1 expression-mediated inflammation via receptor t yrosine kinases and Elk/p300 in human tracheal smooth muscle cells. Am. J. Physiol. Lung Mol. Cell. Biol., 309(3):L211-L225. 2015, Aug. Physiology, 14/83=16.87%, IF=4.080. 

81. Lin, C.C., C.S. Pan, C.Y. Wang, S.W. Liu, L.D. Hsiao, and C.M. Yang.* Tumor necrosis factor-a induces VCAM-1-mediated inflammation via c-Src-dependent transactivation of EGF receptors in human cardiac fibroblasts. J. Biomed. Sci., 2015, 22:53-67, JulMEDICINE, RESEARCH & EXPERIMENTAL, 50/123=40.65%, IF= 2.763.

82. Hsu C.K., C.C. Lin, I.T. Lee, L.D. Hsiao, and C.M. Yang.* Mevastatin ameliorates sphingosine-1-phosphate-induced COX-2/PGE2-dependent cell migration via FoxO1 and CREB translocation. Br. J. Pharmacol. 172(22):5360-76, 2015,NovPharmacology, 24/254=9.45%, IF=4.842.

83. Chien, P.T., C.C. Lin, L.D. Hsiao, and C.M. Yang.Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes. Toxicol. Appl. Pharmacol. Toxicol. Appl. Pharmacol. 289: 349-359, 2015, Dec. Toxicology, 13/87=14.94%, IF=3.705.

84. Yang, C.C., C.C. Lin, P.T. Chien, L.D. Hsiao, and C.M. Yang.* Thrombin/matrix metalloproteinase-9-dependent SK-N-SH cell migration is mediated through a PLC/PKC/MAPKs/NF-kB cascade. Mol. Neurobiol., 2016, in press. Neuroscience, 36/252=14.29%, IF=5.137.