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School of Nursing


Jan-Kan Chen


Contact Information
Chang Gung University School of Nursing 
259 Wen-Hwa 1st Road, Kwei-Shan Tao-Yuan,Taiwan
TEL:+ 886-3-2118800 ext. 5077
Boston College, USA

Human Physiology
General Biology

Tissue engineering
Stem cell biology
Signaling regulation in cancer cells
  1. p63與人類keratinocytes增殖和分化的關係 (長庚醫院, 2005-2007)
  2. p63和眼球輪部幹細胞分裂及分化的關係(國科會, 2005-2007)
  3. TAp63和delta Np63基因表現的調節機制研究(1/3)(國科會, 2006-2007)
  4. 整合型角膜表層之組織工程研究子計劃一:TAp63和ΔNp63在角膜上皮層發育成熟之功能研究(長庚醫院, 2006-2007)
  5. p63與人類keratinocytes增殖和分化的關係(長庚醫院, 2007-2008)
  6. TAp63和 delta Np63基因表現的調節機制研究(2/3)(國科會, 2007-2008)
  7. TAp63和 delta Np63基因表現的調節機制研究(3/3)(國科會, 2008-2009)
  8. Resveratrol改善糖尿病大鼠血管病變之作用機制(1/3)(長庚醫院, 2008-2009)

  1. Chu W. K., Lee K.C., Chow S.E. and Chen J.K. (2006) Dual regulation of the Np63 transcriptional activity by Np63 in human nasopharyngeal carcinoma cell. Biochemical and Biophysical Research Communications. 342:1356-1360.
  2. Su, H. C., Hung L.M. and Chen J.K. (2006) Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin -induced diabetic rats. Am. J. Physiol. Endocrinol and Metab. 290:E1339-E1346.
  3. Hung C. F., Chen J. K. Liao M. H., Lo H. M. and Fang J. Y. (2006) Development and evaluation of emulsion-liposome blends for resveratrol delivery. Journal of Nanoscience and Nanotechnology. 6:2950-2958.
  4. Sun C. C., Pang Su J. H., Cheng C. Y., Cheng H. F., Lee Y. S., Ku W. C., Hsiao C. H., Chen J. K. and Yang C. M. (2006) Interleukin-1 receptor antagonist (IL-1RA) prevents apoptosis in ex vivo expansion of human limbal epithelial cells cultivated on human amniotic membrane. Stem Cell. 24:2130.2139.
  5. Ma D. H. K., Chen J. K., Zhang F., Lin K. Y., Yao J. Y. and Yu J. S.(2006) Regulation of corneal angiogenesis in limbal stem cell deficiency. Progress in Retinal and Eye Research. 25:563-590.
  6. Lin Y. C., You L., Xu Z., He B., Mikami I., Thung E., Chou J., Kuchenbecker K., Kim J., Raz D., Yang C. T., Chen J. K., Jablons D. M. (2006) Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. Biochemical and Biophysical Research Communication. 341: 635-640
  7. Chow S. E., Hshu Y. C., Wang J. S., and Chen J. K. (2007) Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages. J Appl Physiol. 102: 1520-1527.
  8. Liu S. J., Chi P. S., Lin S. S., Ueng S. W. N., Chan E. C., and Chen J. K. (2007) Novel solvent-free fabrication of biodegradable poly-lactic-glycolic acid (PLGA) capsules for antibiotics and rhBMP-2 delivery. International Journal of Pharmaceutics 330: 45-53.
  9. Tsai S. H., Liu Y. W., Tang W. C., Zhou Z. W., Hwang C. Y., Hwang G. Y., Ou B. R., Hu C. P., Yang V. C., and Chen J. K. (2007) Characterization of porcine arterial endothelial cells cultured on amniotic membrane, a potential matrix for vascular tissue engineering. Biochemical and Biophysical Research Communication. 357: 984-990.
  10. Lin Y. C., You L., Xu Z., He B., Yang C. T., Chen J. K., Mikami I., Clément G., Shi Y., Kuchenbecker K., Okamoto J., Kashani-Sabet M., and Jablons D. M. (2007) Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth. Human Gene Therapy. 18: 379-386.
  11. Kuo P. C., Kao C. H., Chen J. K. (2007) Glycated typeⅠ collagen induces endothelial dysfunction in culture. In Vitro Cell Dev. Biol. 43:338-343.
  12. Lu C. C., Lai H. C., Hsieh S. C., Chen J. K. (2008) Resveratrol ameliorates Serratia marcescens-induced acute pneumonia in rats. J. Leukocyte Biol. 83:1028-1037.
  13. Chu W. K., Dai P. M., Li H. L., Chen J. K. (2008) Transcriptional activity of the △Np63 promoter is regulated by STAT3. J. Biol. Chem. 283:7328-7337.
  14. Chu W. K., Dai P. M., Li H. L., Chen J. K. (2008) Glycogen synthase kinase-3β regulates △Np63 gene transcription through the β-catenin signaling pathway. Journal of Cellular Biochemistry. 105:447-453.
  15. Chiang C. T., Chu W. K., Chow S. E., Chen J. K. (2008) Overexpression of △Np63 in a human nasopharyngeal carcionoma cell line downregulates CKIs and enhances cell proliferation. J. Cell Physiol. 219:117-122.
  16. Liu S. J., Hsueh C. L., Ueng Steve W. N., Lin S. S., Chen J. K. (2009) Manufacture of solvent-free polylactic-glycolic acid (PLGA) scaffolds for tissue engineering. Asia-pacific journal of chemical engineering. 4:154-160.
  17. Hung-Chi Jesse Chen 1*, Hsiang-Ling Chen 2, Jui-Yang Lai 3, Chih-Chun Chen 4, Yueh-Ju Tsai 5, Ming-Tse Kuo 6, Pao-Hsien Chu 7, Chi-Chin Sun 8, Jan-Kan Chen 9, and David Hui-Kang Ma 5 (2009) Persistence of Transplanted Oral Mucosal Epithelial Cells in Human Cornea. Investigative Ophthalmology and Visual Science.50:4660-4668
  18. Lai S. C., Chen R. S., Wu Chou Y. H., Chang H. C., Kao L. Y., Huang Y. Z., Weng Y.H., Chen J. K., Hwu W. L., Lu C. S. (2009) A longitudinal study of Taiwaness Sialidosis type 1: an insight into the concept of cherry-red spot myoclonus syndrome. European journal of neurology. 16:912-919.
  19. Cheng C. C., Wang D. Y., Kao M. H., Chen J. K. (2009) The growth-promoting effect of KGF on limbal epithelial cells is mediated by upregulation of △Np63α through the p38 pathway. Journal of Cell Science.122:4473-4480.
  20. Lu C.C., Chen J.K. (2010) Resveratrol enhances perforin expression and NK cell cytotoxicity through NKG2D-dependent pathways. Journal of Cellular physiology.
  21. Jing YH, Chen KH, Yang SH, Kuo PC, Chen J.K. (2010) resveratrol ameliorates vasculopathy in stz-induced diabetic rats: role of age-rage signal. Diabetes-Metab. Res. Rev. 26:212-222
  22. Yao J. Y., Pao C. C and Chen J. K. (2010) Transcriptional activity of TAp63 promoter is regulated by c-jun. J cell physiol. 225:898-904
  23. 98. Jeng J. Y., and Chen J. K. (2010) Tap63 plays compensatory roles in p53-deficient cancer cells under genotoxic stress. Biochemical and Biophysical research communication. (in press)